Validated nomogram may Predict upper GI bleeding in peritoneal dialysis Patients: Study
- byDoctor News Daily Team
- 26 September, 2025
- 0 Comments
- 0 Mins

Researchers have found in a new study that Calcium and PPI use, history of upper gastrointestinal bleeding (UGIB), hemoglobin levels, and uric acid were identified as significant predictors of UGIB in peritoneal dialysis (PD) patients. Therefore a validated nomogram based on these factors shows promise as a clinical tool for predicting UGIB risk in this population. The study was published inBMC Nephrologyby Sijia S. and colleagues. This retrospective study involved information from 2,107 PD patients who were treated from February 1, 2007, to November 15, 2021. The patients were split into training and validation groups randomly in a 1:1 ratio. Researchers used the least absolute shrinkage and selection operator (LASSO) regression method to determine candidate UGIB predictors. The predictors were then utilized to create a nomogram model. To test the performance of the nomogram, the accuracy and clinical value of the model were both checked with a variety of metrics, ranging from receiver operating characteristic (ROC) curves and calibration curves to decision curve analysis (DCA). This strict testing guaranteed that the model was not only statistically valid but also useful in practice. Key Findings Of the 2,107 patients examined, 114 had UGIB. Five predictors were found to be predictive of UGIB and were included in the nomogram: Calcium supplement use Proton pump inhibitor (PPI) use History of UGIB The nomogram had excellent predictive performance. The C-index, a measure of model discrimination, was 0.859 (95% CI: 0.810–0.909) in the training set and 0.874 (95% CI: 0.829–0.919) in the validation set. These results reflect high accuracy in separating patients at risk for UGIB. The analysis conclusively demonstrated that the application of calcium and PPIs, history of UGIB, hemoglobin level, and uric acid were the key predictors of UGIB in peritoneal dialysis patients. The reliable nomogram derived from these factors provides a convenient method of estimating the risk of UGIB. It has the potential to be used as a clinical decision-support tool to enhance patient care and outcomes in this high-risk group. Shang, S., Zhang, X., Zhan, X. et al. Development and validation of a predictive model for upper gastrointestinal bleeding in peritoneal dialysis patients: a retrospective, multicenter cohort study. BMC Nephrol 26, 383 (2025).https://doi.org/10.1186/s12882-025-04304-y
Disclaimer: This website is designed for healthcare professionals and serves solely for informational purposes.
The content provided should not be interpreted as medical advice, diagnosis, treatment recommendations, prescriptions, or endorsements of specific medical practices. It is not a replacement for professional medical consultation or the expertise of a licensed healthcare provider.
Given the ever-evolving nature of medical science, we strive to keep our information accurate and up to date. However, we do not guarantee the completeness or accuracy of the content.
If you come across any inconsistencies, please reach out to us at
admin@doctornewsdaily.com.
We do not support or endorse medical opinions, treatments, or recommendations that contradict the advice of qualified healthcare professionals.
By using this website, you agree to our
Terms of Use,
Privacy Policy, and
Advertisement Policy.
For further details, please review our
Full Disclaimer.
Recent News
NMC approves 2,337 new PG medical seats for NEET P...
- 22 October, 2025
Rajasthan MBBS student airlifted from Kazakhstan a...
- 22 October, 2025
NEET SS 2025 now on December 26th, 27th: NBE
- 22 October, 2025
Daily Newsletter
Get all the top stories from Blogs to keep track.
0 Comments
Post a comment
No comments yet. Be the first to comment!