Researchers have found in a new nationwide population-based study published in theJournal of Affective Disordersthat patients with Graves’ disease face a significantly higher risk of developing psychiatric disorders compared with the general population, highlighting the complex interplay between thyroid autoimmunity, neuropsychiatric health, and long-term disease management. The study analyzed a large cohort of individuals diagnosed with Graves’ disease against matched controls and found that the risk was particularly elevated for depression, bipolar disorder, anxiety disorders, and sleep disturbances, with these associations persisting even two years after the initial diagnosis. Interestingly, no significant association was observed between Graves’ disease and the risk of schizophrenia, suggesting that the thyroid-psychiatric link may be specific to certain mental health conditions rather than encompassing all psychiatric disorders. These findings underscore the importance of integrating psychological assessment and monitoring into routine clinical care for patients with Graves’ disease, as mental health complications may extend beyond the acute phase of endocrine dysfunction and persist well into long-term follow-up. The mechanisms underlying these associations may involve immune-mediated pathways, alterations in thyroid hormone regulation affecting neurotransmitter systems, chronic disease burden, or psychosocial stressors related to living with a long-term autoimmune condition. For clinicians, the results reinforce the need for interdisciplinary collaboration between endocrinologists, psychiatrists, and primary care physicians to ensure early detection and appropriate management of psychiatric symptoms in patients with Graves’ disease. For patients, the findings highlight the importance of awareness regarding mood changes, anxiety, or sleep disturbances as possible complications linked to their thyroid condition, emphasizing the role of proactive mental health care in improving quality of life and treatment outcomes. While the study provides robust evidence from a large dataset, further research is warranted to explore causal mechanisms, evaluate the impact of antithyroid treatments on psychiatric risk, and determine whether early psychological interventions can mitigate long-term complications. Overall, the study strengthens the argument for holistic management approaches that address both the endocrine and psychological dimensions of Graves’ disease. Keywords:Graves’ disease, psychiatric disorders, depression, bipolar disorder, anxiety, sleep disorder, thyroid autoimmunity, Journal of Affective Disorders Reference:Journal of Affective Disorders.“Risk of psychiatric disorders in patients with Graves’ disease: A nationwide population-based analysis.” Published September 16, 2025. DOI: 10.1016/j.jad.2025.09.041.