USA: A study published in theJournal of Wound Carehas revealed that a botanical-based hydrogel was as effective as standardhydrogelin treatingdiabetic foot ulcers. In a trial involving 65 patients, the botanical gel provided greaterpain reliefand better reduction in wound surface area. Led by Dr. Windy Cole, DPM, CWSP, FFPM (Glasg), Adjunct Professor at Kent State University College of Podiatric Medicine, the research explored the therapeutic benefits of a plant-based wound gel—LAVIOR Diabetic Wound Gel (LDWG)—in comparison to a widely used standard product, SoloSite Wound Gel (SSWG). The prospective, double-blind, randomized controlled trial involved 65 participants with diabetic foot ulcers (DFUs), a notoriously difficult-to-heal complication of diabetes. Patients were randomly assigned to one of two groups: 34 received treatment with the botanical LDWG, while 31 were treated with the standard SSWG. Both groups were monitored weekly over six weeks, with progress assessed through wound surface measurements, pain levels, and scores from the Diabetic Foot Scale (DFS)—a validated tool for evaluating patient-reported outcomes in DFU care. The study revealed the following findings: “The study reinforces the potential of botanical hydrogels like LDWG in managing hard-to-heal wounds such as diabetic foot ulcers,” the authors noted. “Particularly, the pain reduction benefits and consistent wound healing progression suggest that LDWG could serve as a valuable tool in wound care.” Despite encouraging results, the researchers acknowledge limitations. The relatively small sample size and a short follow-up period of five weeks may not fully capture long-term healing trends, especially in chronic wounds. The team suggests that larger, multicenter trials are essential to confirm these early findings and explore the broader applications of Inula viscosa ‘AGS-RIED’, the botanical extract used in LDWG. "While both treatment options proved beneficial, LDWG not only matched the traditional hydrogel in healing diabetic foot ulcers but also offered better pain control and promising wound reduction outcomes. These findings support further research into botanical-based solutions as viable, patient-friendly alternatives in wound management," the authors concluded. Bae SHS, Cole W, Davis IM, Sandler D, Warren JD, Mackenzie JS. Healing wounds with a multimodal botanical hydrogel: a clinical outcomes comparison study. J Wound Care. 2025 Jul 1;34(Sup7):S5-S12. doi: 10.12968/jowc.2025.0185. PMID: 40632779.