A review published in the International Urogynecology Journal found that synthetic mid-urethral slings (sMUS) offers interesting success rates and acceptable morbidity which makes it considerable for the treatment of stress urinary incontinence (SUI) in women with neurogenic lower urinary tract dysfunction (NLUTD).
The study team led by Clément Sarrazin evaluated the safety and efficacy of sMUS in women with NLUTD for the treatment of SUI. The study performed a systematic review of the literature, including MEDLINE, Embase, and Cochrane controlled trials databases from January 1995 to April 2021. Nine studies were included, representing 298 patients, with a mean age of 52 years and median follow-up of 41.3 months.
The primary outcome was the success of the surgery according to study criteria, and secondary outcomes were complications, particularly de novo urgency, urinary retention, tape exposure, and revision for complications. The study found that sMUS insertion was successful in 79.5% of patients, with a median rate of de novo urgency of 15.7%, a median rate of retention of 19.3%, and 21 out of 26 patients required intermittent self-catheterisation. Four cases of tape exposure were reported, and 8 patients underwent a revision for complications.
However, further studies are required to define which patients would be more likely to benefit from this intervention, as well as its place among the other surgical treatments for SUI. The findings of this study suggest that sMUS could be a viable option for the treatment of SUI in women with NLUTD, but additional research is needed to fully assess its efficacy and safety.
Source:
Sarrazin, C., Baron, M., Thuillier, C., Ruffion, A., Perrouin-Verbe, M.-A., & Fiard, G. (2021). Synthetic mid-urethral slings for the treatment of stress urinary incontinence in women with neurogenic lower urinary tract dysfunction: a systematic review. In International Urogynecology Journal (Vol. 33, Issue 4, pp. 767–776). Springer Science and Business Media LLC. https://doi.org/10.1007/s00192-021-04929-1