Cardiology and CTVS

SLE Linked To Higher Risk Of Heart Failure And Mortality ;JACC

• byDoctor News Daily Team
• 18 February, 2025
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Recent research has highlighted that SLE patients had a higher associated risk of heart failure and other cardiovascular outcomes compared with matched control subjects. Researchers have further comfirmed that among patients developing HF, a history of SLE was associated with higher mortality. The findings have been published in Journal of the American College of Cardiology.
To date,data on long-term cardiovascular outcomes in systemic lupus erythematosus (SLE) are sparse.On such premises,This study sought to examine the long-term risk and prognosis associated with cardiovascular outcomes, including heart failure (HF), in patients with SLE.
For the study design,using Danish administrative registries, risks of outcomes were compared between SLE patients (diagnosed 1996 to 2018, no history of cardiovascular disease) and age-, sex-, and comorbidity-matched control subjects from the background population (matched 1:4). Furthermore, mortality following HF diagnosis was compared between SLE patients developing HF and age- and sex-matched non-SLE control subjects with HF (matched 1:4).
Data analysis revealed some interesting facts.
A total of 3,411 SLE patients (median age: 44.6 years [25th to 75th percentile: 31.9 to 57.0 years]; 14.1% men) were matched with 13,644 control subjects. The median follow-up was 8.5 years (25th to 75th percentile: 4.0 to 14.4 years).
Absolute 10-year risks of outcomes were: HF, 3.71% (95% confidence interval [CI]: 3.02% to 4.51%) for SLE patients, 1.94% (95% CI: 1.68% to 2.24%) for control subjects; atrial fibrillation, 4.35% (95% CI: 3.61% to 5.18%) for SLE patients, 2.82% (95% CI: 2.50% to 3.16%) for control subjects; ischemic stroke, 3.75% (95% CI: 3.06% to 4.54%) for SLE patients, 1.92% (95% CI: 1.66% to 2.20%) for control subjects; myocardial infarction, 2.17% (95% CI: 1.66% to 2.80%) for SLE patients, 1.49% (95% CI: 1.26% to 1.75%) for control subjects; venous thromboembolism, 6.03% (95% CI: 5.17% to 6.98%) for SLE patients, 1.68% (95% CI: 1.44% to 1.95%) for control subjects; and the composite of implantable cardioverter-defibrillator implantation/ventricular arrhythmias/cardiac arrest, 0.89% (95% CI: 0.58% to 1.31%) for SLE patients, 0.30% (95% CI: 0.20% to 0.43%) for control subjects.
SLE with subsequent HF was associated with higher mortality compared with HF without SLE (adjusted hazard ratio: 1.50; 95% CI: 1.08 to 2.08).
For full article follow the link: Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus J Am Coll Cardiol 2021 Apr 13;77(14)1717-1727, A Yafasova, EL Fosbøl, M Schou, B Baslund, M Faurschou, KF Docherty, PS Jhund, JJV McMurray, G Sun, SL Kristensen, C Torp-Pedersen, L Køber, JH Butt
Primary source: Journal of the American College of Cardiology