A new systematic review and meta-analysis published inFrontiers in Pediatricshighlights the prognostic value of red blood cell distribution width (RDW) in critically ill pediatric patients, suggesting it could be an important and easily accessible biomarker for early risk stratification. Researchers analyzed data from 10 studies encompassing 6,327 children admitted to pediatric intensive care units (PICUs) and examined the association between RDW levels and mortality outcomes. The findings revealed a strong correlation between elevated RDW and increased risk of death, with each incremental rise in RDW linked to a 24% higher odds of mortality (odds ratio [OR] 1.24, 95% CI 1.14–1.35). Furthermore, patients presenting with high RDW values had a 73% greater risk of death compared with those with normal RDW (OR 1.73, 95% CI 1.47–2.05). These associations remained consistent across different study designs, populations, and adjustment models, underscoring the robustness of the results. RDW, a measure routinely available in complete blood counts, reflects variability in red blood cell size and is influenced by inflammation, oxidative stress, and nutritional deficiencies—factors that are frequently encountered in critically ill patients. The authors emphasized that the use of RDW as a prognostic marker has practical advantages: it is inexpensive, widely available, and non-invasive, making it especially valuable in resource-limited settings. While the study did not establish RDW as a causal factor for poor outcomes, it reinforced its role as a surrogate marker of underlying disease severity and systemic stress. Clinicians may consider incorporating RDW into early risk assessment models to identify high-risk patients and tailor monitoring and interventions more effectively. The authors also called for future prospective studies to validate cut-off values, explore integration with other prognostic indices, and assess whether RDW-guided interventions could improve survival outcomes in pediatric critical care. Overall, the evidence positions RDW as a promising, readily available biomarker that could enhance clinical decision-making in the management of critically ill children. Keywords:red blood cell distribution width, RDW, pediatric intensive care, mortality, biomarker, prognosis, meta-analysis