Pediatric Large Vessel Occlusion (LVO) Stroke Study

The natural history of pediatric patients with large vessel occlusion (LVO) stroke treated conservatively is poor, but is usually improved by thrombectomy, according to a recent study published in the JAMA Neurology.

The incidence and natural history of large vessel occlusion (LVO) stroke in children are largely unknown. These knowledge gaps limit the uptake of reperfusion therapies and reduce the efficiency of pediatric acute stroke pathways.

Study Overview

A study was conducted to determine the incidence and natural history of pediatric large vessel occlusion (LVO) stroke.

This retrospective population-based cohort study was conducted between January 2010 and December 2019, with a mean (SD) follow-up of 37.0 (28.8) months. Admissions from all pediatric hospitals in the state of New South Wales, Australia, with a final diagnosis of arterial ischemic stroke (AIS) in patients 1 month to younger than 17 years were included. A total of 85 of 251 identified cases were excluded based on selection criteria. Data were analyzed from July 2020 to June 2021.

One-third of patients with LVO received mechanical thrombectomy with or without intravenous thrombolysis while the remainder were treated conservatively. The primary outcome was the pediatric modified Rankin Scale (ped-mRS) score 3 months after stroke. Ordinal logistic regression was used to compare non-LVO, LVO without thrombectomy, and LVO with thrombectomy groups.

Results

• Of 161 included patients, 56 (34.8%) were female, and the mean (SD) age was 6.1 (5.4) years.
• A total of 166 AIS admissions were studied, and clinical follow-up was available for 164 of 166 admissions.
• LVO was present in 39 admissions (23.5%).
• The incidence of LVO stroke was 0.24 per 100,000 patients per year (95% CI, 0.13-0.35).
• Patients with LVO who did not receive thrombectomy (n = 26) had poor neurological outcomes, with 19 (73.1%) experiencing moderate to severe disability or death (ped-mRS score of 3 to 6) at 3 months.
• 6 of 12 patients receiving thrombectomy (50.0%); 25 of 38 patients with LVO (65.8%).
• Patients with LVO without thrombectomy had significantly worse clinical outcomes than patients with non-LVO at 3 months (odds ratio, 3.64; 95% CI, 1.68-7.87; P = .001).
• Most patients with large vessel occlusion (LVO) presented within time windows suitable for thrombectomy (27 of 39 [69.2%] within 6 hours; 35 of 39 [89.7%] within 24 hours).

Thus, in this population-based cohort study, the natural history of pediatric patients with large vessel occlusion (LVO) stroke treated conservatively was poor, with most experiencing lifelong disability or death. Nearly 90% of pediatric patients with large vessel occlusion (LVO) presented within time windows suitable for thrombectomy.

Reference

Incidence and Natural History of Pediatric Large Vessel Occlusion Stroke: A Population Study by Kartik D Bhatia et al. published in the JAMA Neurology.

https://pubmed.ncbi.nlm.nih.gov/35344005/