Lucknow, Uttar Pradesh: Nephrolithiasis is highly prevalent in patients with metabolic syndrome, suggests a recent study in the Journal of the Association of Physicians of India. The study also found a significant correlation between risk factors of nephrolithiasis and various metabolic syndrome components.
The rise in incidence of nephrolithiasis in recent decades coincides with the increasing epidemic of type 2 diabetes, metabolic syndrome, and obesity. This concordance suggests a possible link between metabolic abnormalities and urinary stone disease. Therefore, Ritu Karoli, Professor(Junior Gr.), Dept. of Medicine, Dr. RMLIMS, Lucknow, Uttar Pradesh, and colleagues aimed to investigate the association between presence of risk factors of nephrolithiasis and metabolic syndrome.
The hospital-based, case control study included hundred patients of metabolic syndrome diagnosed according to IDF criteria. Hundred age and matched controls were studied for presence of risk factors of nephrolithiasis.
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Key findings of the study include:
Patients with metabolic syndrome had significantly higher uricosuria,hypercalciuria,oxaluria and hypocitraturia.
The prevalence of risk factors of nephrolithiasis was also higher in patients with metabolic syndrome.
The most prevalent was low urinary pH in 40% patients with mean pH of 5.8±1.6.
Amongst other factors, 33% had hyperuricemia, 29% had hypercalciuria, 15% had oxaluria 13% had hypocitraturia and 10% had hyperuricosuria.
Significant correlation was observed between risk factors of nephrolithiasis and components of metabolic syndrome.
Our findings provides an evidence of association between risk factors of nephrolithiasis and metabolic syndrome and suggests that nephrolithiasis may be a systemic disorder representing the interaction of multiple metabolic derangements," wrote the authors.
"Determining common modifiable risk factors for the development of kidney stones might uncover new preventive strategies," they concluded.
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"Study of Association of Metabolic Syndrome and Risk Factors of Nephrolithiasis," is published in the Journal of the Association of Physicians of India.
DOI: https://www.japi.org/x2747474/study-of-association-of-metabolic-syndrome-and-risk-factors-of-nephrolithiasis