October 29, 2025

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Newly prescribed Benzodiazepine or Antipsychotic Use tied to Higher Mortality in Dementia Patients: JAMA

A case-control study of Medicare data has found that older adults with Alzheimer’s disease or other forms of dementia who were newly prescribed benzodiazepines or antipsychotics in hospice care had higher mortality compared with those not receiving these medications. The study, published in JAMA Network Open by Wang L. and colleagues, analyzed prescribing patterns and outcomes in a large population of hospice patients. Researchers noted that these medications were typically initiated about three days after hospice enrollment, with patients having an average hospice stay of over 135 days. The findings underscore the potential risks associated with psychotropic medication use in vulnerable populations with advanced cognitive decline.

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