October 31, 2025

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Meta-Analysis Confirms COVID-19 Vaccination in Pregnancy Protects Both Mother and Baby Safely

An analysis of data from over 1.2 millionpregnantindividuals found that those who received aCOVID-19vaccination had a 58% lower risk of being infected with the virus, as well as a lower risk of experiencing a stillbirth orpreterm birth, according to research presented during the American Academy of Pediatrics 2025 National Conference & Exhibition at the Colorado Convention Center from Sept. 26-30. For the study, the author conducted a systematic search where she included 23 meta-analyses inclusive of over 200 studies and 1,250,000 pregnant individuals with documented COVID-19 vaccination. We found that the COVID-19 vaccination during pregnancy offers significant protections tonewbornsand mothers,” said Nikan Zargarzadeh, study author and Harvard University research fellow. “This information can help support informed decision-making for pregnant individuals and their care teams.” The review found those who received a COVID-19 vaccination during pregnancy had an 8% lower risk of preterm birth before 37 weeks and a 34% lower risk of preterm birth before 28 weeks. Vaccination was also associated with an 25% lower risk of stillbirth and an 9% lower risk of neonatal intensive care admission, as well as a 17% lower risk of congenital anomalies, according to the study abstract. There were no increased risks observed for maternal hospitalization, intensive care admission, gestational diabetes, hypertension, or pre-eclampsia. Ref:Meta-analysis: COVID-19 vaccination during pregnancy is safe and beneficial for mother and infant; American Academy of Pediatrics

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