A recent systematic review has found that low-carbohydrate diets (LCDs) and ketogenic diets (KDs) are effective and viable strategies for achieving and maintaining remission in Type 2 Diabetes Mellitus (T2DM). The findings have been published in the September issue of Cureus. Long-term trial data shows that these dietary approaches significantly improve glycemic control, body weight, and overall cardiometabolic health, with a notable subset of individuals sustaining remission for several years. Type 2 Diabetes Mellitus (T2DM) is severe global public health crisis, with the number of affected individuals rising dramatically from 200 million in 1990 to 830 million in 2022. If left unmanaged, T2DM can lead to serious complications, including kidney failure, retinopathy, neuropathy, and cardiovascular disease. Although pharmacological treatments are available, achieving sustained glycemic control and long-term remission in type 2 diabetes mellitus (T2DM) remains challenging. Dietary approaches, particularly low-carbohydrate diets (LCDs) and ketogenic diets (KDs), are increasingly being explored for their potential to improve metabolic health and promote T2DM remission (achieving HbA1c of <6.5% without taking glucose lowering medication). The current systematic review assessed the long-term effectiveness and safety of LCDs and KDs in the management and possible remission of T2DM. Researchers searched PubMed and the Cochrane Library for open-access studies between 2000 and 2024, involving adults (≥18 years) with type 2 diabetes who followed a low-carbohydrate diet (50–130 g/day) or ketogenic diet (≤50 g/day) for at least 12 months. Of 124 studies identified, six met all inclusion criteria. Follow-up ranged from one to eight years and included both randomized and non-randomized trials. Primary outcomes assessed were T2DM remission, HbA1c, body weight, and BMI; secondary outcomes included blood pressure, lipid profiles, and adverse events. Key findings from the study include: This systematic review showed long-term evidence that low-carbohydrate and ketogenic diets are effective and sustainable for long-term remission in T2DM. They improved glycemic control, body weight, and cardiometabolic health, offering a noninvasive alternative to pharmacological treatment. However, long-term adherence remains a challenge. Future research should refine dietary guidelines, identify ideal patient groups, and assess quality-of-life and safety impacts to integrate such interventions into standard diabetes care. Reference:Das R, Mohammad N, Islam M, et al. (September 27, 2025) Long-Term Efficacy and Safety of a Low-Carbohydrate Diet in Type 2 Diabetes Remission: A Systematic Review. Cureus 17(9): e93340. doi:10.7759/cureus.93340