July 20, 2025

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The text you provided discusses uterine transplantation (UTx), a novel medical procedure that allows women who are unable to conceive due to absolute uterine factor infertility (AUFI) to become mothers. Here's an overview of the main points: 1. Uterine transplantation involves using a donated uterus, which is transplanted into the recipient's body and allows for pregnancy and childbirth. 2. The procedure is associated with significant morbidity, including major surgeries (UTx, caesarean section/s, and hysterectomy to remove the transplant) and the risks associated with temporary immunosuppression. 3. Recipients must be highly motivated, have excellent support networks, access to appropriate psychological services, and be fully informed of the potential risks involved. 4. The use of living donors is common, but it necessitates consideration of the significant potential risk to the donor. Counselling and support for donors are essential, including access to psychological services if required. 5. Only extensively counselled, fully informed women can decide whether the potential benefit of UTx outweighs the significant risks associated with the process. 6. The long-term future of UTx will likely focus on the development of a bioengineered uterine graft to alleviate donor shortages and surgical risk for the donor and immunosuppression-related risk in the recipient. 7. There are more than 40 procedures using living donors, resulting in at least 20 live births so far, with transition into clinical practice expected in the future. The use of deceased donors remains a research concept, with further cases needed for comparison between the efficacy of each donor type. 8. Due to the procedure's novelty, long-term outcomes following UTx are not yet available, and all cases should be registered with an international registry for follow-up. The text also mentions that psychological evaluations, counselling, and follow-up are required for both recipients and donors, as the procedure can have significant psychological implications. Additionally, it emphasizes that only women who are fully informed of the potential risks involved should consider undergoing uterine transplantation.

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