Cardiology and CTVS

Higher TyG Index Linked With Early-Onset ASCVD And All-Cause Mortality, Claims Study

• byDoctor News Daily Team
• 18 February, 2025
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Researchers have found that a higher triglyceride glucose (TyG) index is significantly associated with an increased risk of early-onset atherosclerotic cardiovascular disease (ASCVD) events. This risk also extends to all-cause mortality in young and middle-aged populations from North China. This study was published in Cardiovascular Diabetology by Qiqi H. and colleagues. The Kailuan Study, which followed 64,489 participants, demonstrates the importance of monitoring and managing the TyG index to reduce the risk of ASCVD and premature death in these age groups.

Early-onset ASCVD and all-cause mortality pose significant health risks to young and middle-aged populations. The TyG index, a marker of insulin resistance, may play a role in the development of ASCVD events and mortality. The Kailuan Study provides new insight into the relationship between the TyG index and these health risks.
The study included 64,489 young and middle-aged participants from the 2006 Kailuan Study physical examination. Multivariate Cox proportional hazards models and restricted cubic spline curves were used to assess the association between the TyG index and the risk of early-onset ASCVD events and all-cause mortality.
The key findings of the study were as follows:
• During a median follow-up period of 11 years:
• 1,984 participants (3.08%) experienced at least one ASCVD event.
• 1,392 participants (2.16%) experienced all-cause death.
• A higher TyG index was significantly associated with a higher risk of early-onset ASCVD events (HR: 1.61, 95% CI 1.38–1.89) and all-cause mortality (HR: 1.39, 95% CI 1.17–1.65).
• For each unit increase in the TyG index, the risk of early-onset ASCVD events increased by 20%.
• There was a non-linear association between the TyG index and early-onset ASCVD events (P for non-linear <0.01).
• A linear association between the TyG index and all-cause mortality was observed (P for non-linear = 0.476).
The study demonstrates a significant association between a higher TyG index and an increased risk of early-onset ASCVD events and all-cause mortality in a young and middle-aged population from North China. These findings emphasize the need for monitoring and managing the TyG index to reduce the risk of early-onset ASCVD and mortality.
Reference:
Hou, Q., Qi, Q., Han, Q., Yu, J., Wu, J., Yang, H., Chen, S., Wu, S., & Li, K. (2024). Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study. Cardiovascular Diabetology, 23(1). https://doi.org/10.1186/s12933-024-02249-4