Glipizide and Metformin FDC - Effective, Safe and Cost-Effective in T2D: Latest Indian Real-World Study
A real-world Indian study found that glipizide, alone or with metformin, improves glycemic control in patients with declining renal function without impacting weight or beta-cell function. This study has been conducted by leading researchers and endocrinologist V. Mohan, TA Pramod Kumar, Rajendra Pradeepa, Saravanan Jebarani, Sadasivam Ganesan, Abhijit Pednekar, Routray Philips, Suraparaju Pavan Kumar, Ranjit Unnikrishnan, Ranjit Mohan Anjana and published in the journalDrugs - Real World Outcomes. This retrospective study, conducted at a tertiary diabetes center in India covering an extensive 30-year span of Diabetes Electronic Medical Records (DEMR), including 11,949 adultswith type 2 diabetes treated with glipizide or glipizide with metformin. Patients had at least one follow-up within a year. The primary outcome was change in HbA1c, while secondary outcomes included fasting and postprandial glucose, body mass index (BMI), and estimated glomerular filtration rate (eGFR). The results revealed findings which include: These findings suggest that glipizide, one of the oldest antidiabetic drugs, and its use in combination with metformin remain safe and effective, both as monotherapy and in combination, particularly in specific situations within resource-constrained settings like India. Furthermore, glipizide with metformin, costing just ₹121 monthly, is among the most affordable antidiabetic treatment options in India, improving access for deserving lower-income groups living with T2D. 1) PramodKumar TA, Pradeepa R, Jebarani S, Ganesan S, Pednekar A, Philips R, Kumar SP, Unnikrishnan R, Anjana RM, Mohan V. Effectiveness of Glipizide and Glipizide Plus Metformin Formulation among Asian Indians with Type 2 Diabetes: a Real-World, Retrospective Electronic Medical Record Analysis. Drugs Real World Outcomes. 2025 Sep;12(3):457-466. doi: 10.1007/s40801-025-00502-0. Epub 2025 Jul 10. PMID: 40637807; PMCID: PMC12381306.
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