October 23, 2025

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First-in-Human Study Shows Promise for High-Voltage PFA in Treating Scar-Related ventricular tachycardia: Study

According to a new study, a high-voltage pulsed field ablation catheter effectively created transmural ventricular lesions, offering a potential new approach for managing scar-related ventricular tachycardia. Ventricular tachycardia associated with myocardial scarring is a challenging arrhythmia to treat, often requiring complex catheter ablation procedures that carry risks such as collateral tissue damage and incomplete lesion formation. Pulsed field ablation delivers high-voltage electrical pulses in very short durations, selectively affecting myocardial tissue while sparing surrounding structures. This approach may enhance procedural safety and efficacy, particularly in patients with scarred myocardium where conventional radiofrequency or cryoablation techniques can be less predictable.

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