UK: Cemented hemiarthroplasty versus uncemented hemiarthroplasty in elderly patients with an intracapsular hip fracture is tied to modest but significantly better quality of life and a lower risk of periprosthetic fracture, states a recent study. The study was published in the New England Journal of Medicine on February 10, 2022.
The use of bone cement in hip fractures treated with hemiarthroplasty is controversial. Not much data is available on the quality of life after cemented as compared with modern uncemented hemiarthroplasties. Considering this, Miguel A. Fernandez, and colleagues aimed to compare cemented with uncemented hemiarthroplasty in patients 60 years of age or older with an intracapsular hip fracture in a multicenter, randomized, controlled trial.
Health-related quality of life measured with the use of utility scores on the EuroQol Group 5-Dimension (EQ-5D) questionnaire at 4 months after randomization was the primary outcome. Range of scores, −0.594 to 1, higher score indicates better quality of life; range for minimal clinically important difference, 0.050 to 0.075.
A total of 610 patients underwent cemented hemiarthroplasty and 615 underwent modern uncemented hemiarthroplasty; follow-up data were available for 71.6% of the patients at 4 months.
Following were the study's key findings:
The mean EQ-5D utility score was 0.371 in patients assigned to the cemented group and 0.315 in those assigned to the uncemented group (adjusted difference, 0.055).
The between-group difference at 1 month was similar to that at 4 months, but the difference at 12 months was smaller than that at 4 months.
Mortality at 12 months was 23.9% in the cemented group and 27.8% in the uncemented group (odds ratio for death, 0.80).
Periprosthetic fractures occurred in 0.5% and 2.1% of the patients in the respective groups (odds ratio [uncemented vs. cemented], 4.37).
The incidences of other complications were similar in the two groups.
"In patients 60 years of age or older having an intracapsular hip fracture, cemented hemiarthroplasty versus uncemented hemiarthroplasty resulted in a modestly but significantly better quality of life and a lower risk of periprosthetic fracture," the auhtors concluded.
Reference:
The study titled, "Cemented or Uncemented Hemiarthroplasty for Intracapsular Hip Fracture," was published in the New England Journal of Medicine.
DOI: 10.1056/NEJMoa2108337