USA: Hyperdilute Calcium Hydroxylapatite (CaHA) and Chest Wrinkles

Hyperdilute calcium hydroxylapatite (CaHA) significantly improves the appearance of chest wrinkles that persists for at least 1 year, finds a recent study in the Journal of Drugs in Dermatology.

CaHA is used for the treatment of moderate-to-severe facial wrinkles and folds. Its beneficial effects are due to its ability to produce immediate augmentation of soft tissue and a prolonged neocollagenesis with long-term deposition of new collagen.

Hyperdilute CaHA is being used increasingly for stimulating neocollagenesis for improving skin firmness and quality. The study by Sabrina G. Fabi from San Diego, CA, and colleagues aimed to assess the long-term effects of hyperdilute CaHA for improving chest wrinkle appearance.

The study included 20 adult female patients treated with a 1:2 dilution of CaHA. They were evaluated at week 6, week 12, day 180, and day 360 using validated Merz Décolletage Scales. A Subject Satisfaction Questionnaire was used for the assessment of overall satisfaction on a scale from 0 (Completely Dissatisfied) to 6 (Completely Satisfied).

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Key Findings of the Study

• Subjects achieved significant improvements in baseline Merz Décolletage Scale–Dynamic scores at week 6, after a single treatment, at week 12 (two treatments), day 180, and day 360.
• Subjects also demonstrated significant improvement in baseline Merz Décolletage Scale–At Rest scores at week 6, remaining significant at week 12, day 180, and day 360.
• Subject Satisfaction scores increased from 3.25 at day 180 to 3.59 at day 360 using a 7-point scale.

"Hyperdilute CaHA significantly improves the dynamic and resting appearance of wrinkles of the décolleté. These durable improvements persist for at least 1 year," wrote the authors.

Reference

The study titled, "Prospective Clinical Trial Evaluating the Long-Term Safety and Efficacy of Calcium Hydroxylapatite for Chest Rejuvenation," is published in the Journal of Drugs in Dermatology.

DOI: https://jddonline.com/articles/dermatology/S1545961621P0534X