A recent study published inPeriodontology 2000reports that platelet-rich fibrin (PRF), due to its autologous nature and sustained release of bioactive factors, can modulate inflammation and enhance tissue healing in dental procedures. The findings suggest that PRF may improve patient comfort and accelerate recovery while supporting regenerative outcomes. Its ability to provide a natural scaffold and deliver growth factors over time positions it as a promising adjunct in oral surgical and periodontal treatments. The researchers analyzed the mechanisms through which PRF exerts its therapeutic effects. By using autologous blood products, PRF minimizes the risk of immunogenic reactions and promotes localized delivery of key growth factors such as platelet-derived growth factor, vascular endothelial growth factor, and transforming growth factor-β. These factors aid in angiogenesis, cell proliferation, and tissue remodeling, which collectively support faster and more predictable healing of soft and hard tissues. Clinically, patients receiving PRF reported less postoperative pain and swelling, along with improved wound closure and reduced complications, highlighting the potential for enhanced patient outcomes. Despite its promise, the authors emphasize the need for standardized protocols and comparative trials. Variability in PRF preparation methods, patient factors, and outcome measures makes it difficult to draw definitive conclusions about efficacy across procedures. Future research should focus on well-designed randomized controlled trials that evaluate PRF against conventional treatment options, with consistent reporting of clinical and patient-centered outcomes. Such studies will help integrate PRF more confidently into evidence-based dental practice, guiding clinicians on its optimal application for surgical, regenerative, and periodontal procedures. Keywords:platelet-rich fibrin, PRF, tissue healing, autologous biomaterials, dental surgery, periodontal regeneration, inflammation modulation, patient recovery, Periodontology 2000